Beaker List – Yale Edition
Top Entrepreneurial Life Science Professors @ Yale
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Alix Ventures: Supporting Early Stage Life Science Startups Engineering Biology to Drive Radical Advances in Human Health
Overview
Behind every transformative technology is a team of brilliant scientists and researchers. Academic research in particular is a driving force for technological innovation. Here, we have identified a ‘Midas List’ of researchers who have pioneered highly transformative technologies that have translated to the clinic. Using venture backed startups as a primary guide along with other impact metrics such as patents, citations, and thought leadership, the following professors have demonstrated patient impact, providing significant contributions to the startup ecosystem.
Yale University, one of the oldest colleges, has been consistently placed in the highest rankings of United States education programs, perennially among the top five. In the ratings of world research universities, however, Yale tends to be somewhere between tenth and fifteenth. This discrepancy was seen as an opportunity for significant growth by the college in 2016 as Yale has made it a priority in the last half of the decade to become a top leading research university. As an example of the amazing work that this university is producing since this change, we would like to highlight ten professors leading life science entrepreneurship efforts at Yale, both in innovation and strengthening the scientific and entrepreneurial ecosystem of the school.
Aaron Ring
Aaron Ring is an Associate Professor of Immunobiology at Yale University. Ring is best known for his work in directed evolution to create new pharmacologic tools and therapeutics against key immune receptors and cytokine pathways. While an MD/PhD student at Stanford, he co-invented what is now evorpacept, an ultra-high affinity CD47 antagonist under development at ALX Oncology (Nasdaq: ALXO), which he co-founded in 2015. He also co-invented the first CD122-biased IL-2 variant now MDNA-11 at Medicenna Therapeutics. Since joining Yale, Ring and his research team at the Ring Lab, discovered a breakthrough molecule, ‘decoy-resistant’ IL-18 (DR-18), that exerted potent anti-tumor effects in mouse tumor models. The lead DR-18 variant (ST-067) is currently being evaluated in Phase 1 clinical trials as of 2021. In a new research direction, Ring and his team have developed a novel platform for profiling functional autoantibodies in patients called REAP, enabling the identification of therapeutic targets from ‘clinical trials of nature.’
Ring is a named inventor on 24 patents. Since joining Yale, he founded 2 companies: Simcha Therapeutics & Seranova Bio and recently co-founded a third stealth biotech called Stipple Bio.